As we age, structural changes occur in every layer of the skin. The upper skin layer becomes thinner, the fat layer decreases, the number of fibroblasts (cells responsible for producing collagen fibers, elastin fibers, and hyaluronic acid) declines. These changes result in reduced collagen production, leading to skin deterioration — looseness, sagging, and lack of firmness. Collagen plays a vital role, and as its levels decline with age, the skin thins and wrinkles appear.

That’s why innovative products have been developed to help stimulate collagen production — to reinforce the skin’s structure, improve elasticity, and restore firmness and resilience.

What is HArmonyCA?

HArmonyCA is a new hybrid filler innovation that combines facial contouring with skin rejuvenation in a single product. It delivers Duo Effects through a synergistic blend of two natural ingredients.

Main Ingredients in HArmonyCA

1. Hyaluronic Acid (HA): Acts as a carrier for CaHA and provides an instant lifting effect from the very first day of treatment.
2. Calcium Hydroxyapatite (CaHA): Enhances skin firmness and stimulates long-term collagen production. Naturally, CaHA remains in the body for about 1–3 years before it gradually dissolves.

CaHA is a naturally occurring substance found in bones, teeth, and nails. Studies show it stimulates fibroblasts to produce new collagen (neocollagenesis), improving skin firmness. Unlike synthetic polymer-based stimulants, CaHA mimics natural processes, providing subtle and natural-looking results.

How HArmonyCA Works

HArmonyCA is produced using a proprietary crosslinking technology (not Vycross or Hylacross like Juvederm). Under an electron microscope, CaHA particles in HArmonyCA appear as smooth, spherical microspheres sized between 25–45 microns—an optimal range for collagen stimulation in the face. These particles are evenly distributed within the HA gel. A study measured injection pain via osmolarity, which refers to the solute concentration. Ideally, injectable substances should have osmolarity similar to blood to reduce pain. HArmonyCA has an osmolarity of 330 mOsm/mg—within the recommended range—resulting in less injection pain.

Results of HArmonyCA Injection

1. Facial contouring with both skin rejuvenation and volume enhancement
   HArmonyCA is a hybrid filler that delivers a dual-action effect—adding volume where needed while improving overall skin quality. The Hyaluronic Acid (HA) provides instant volumizing and lifting effects, making the skin look plump and smooth right after injection. Simultaneously, Calcium Hydroxyapatite (CaHA) stimulates collagen and elastin production under the skin, leading to firmer and more elastic skin over time.
2. Long-lasting effects up to 12–18 months
   Thanks to advanced manufacturing technology and expert injection techniques by Dr. Som and Dr. Grace, HArmonyCA remains stable in the skin for up to 1 year or more, which is significantly longer than regular fillers that typically last only 6–8 months. This longevity helps reduce the frequency and cost of aesthetic maintenance.
3. Natural-looking results
   HArmonyCA gradually enhances the skin’s structure, making it appear firmer, more lifted, and radiant without giving the impression of being “overfilled.” The outcome is a refined, naturally youthful look that appears as though it occurred on its own.

Where can HArmonyCA be injected?

1. Cheeks
   Helps restore lost volume from fat depletion, correcting sunken cheeks that can make the face appear older. The result is a fuller, brighter look with visibly firmer and lifted skin.
2. Jawline
   Enhances the definition of the facial contour, reduces sagging, and reshapes the jawline to achieve a balanced, well-proportioned facial structure. It boosts confidence with a more defined profile.
3. Chin
   Refines the chin structure for a more harmonious facial balance. Enhances the facial V-shape and contributes to an overall more symmetrical and attractive appearance.

How many sessions of HArmonyCA are needed to see satisfying results?

HArmonyCA typically lasts about 1–2 years. With just one session, you benefit from immediate volume enhancement via HA (Hyaluronic Acid), and long-term collagen stimulation from CaHA (Calcium Hydroxyapatite). Even after the HA naturally dissolves, collagen production continues—helping the skin remain firm and elastic. The duration and effectiveness may vary depending on individual skin conditions and how each person’s skin responds.

Who is HArmonyCA suitable for?

HArmonyCA is ideal for individuals seeking comprehensive facial rejuvenation and lifting, particularly those with skin laxity or loss of elasticity. Suitable candidates can be categorized as follows:

1. Those who have had fillers but want longer-lasting results and collagen stimulation
   Perfect for individuals looking for immediate plumpness from Hyaluronic Acid (HA) and long-term skin structure improvement from Calcium Hydroxyapatite (CaHA).
2. Those who want to restore youthful volume to the face
   Ideal for enhancing areas such as cheeks, nasolabial folds, marionette lines, and jawline. It improves skin elasticity and collagen production, resulting in a healthier, more vibrant complexion.
3. Those who want a natural solution to aging skin
   Suitable for people with fine lines, sagging skin, or thinning skin due to aging or environmental damage (e.g., sun exposure or pollution).
4. Those experiencing collagen depletion
   Great for individuals beginning to lose collagen and skin firmness. HArmonyCA helps firm, hydrate, and strengthen the skin for a more youthful, lifted appearance.

Pre-Treatment Preparation

• Avoid pain relievers like aspirin/ibuprofen, Vitamin E, fish oil, ginseng, garlic for 1–2 weeks
• Avoid alcohol and smoking for 24 hours
• Avoid laser or facial treatments for 1 week
• Avoid intense exercise 24 hours before
• Inform your doctor of any infections, inflammation, or medical conditions

Post-Treatment Care

• Avoid touching, pressing, or massaging the injected area for 2 weeks
• Avoid heat (sauna, steam, sun) for 24 hours
• Avoid exfoliating skincare products for 2 weeks
• Avoid alcohol and smoking for 5–7 days
• Avoid laser/facial treatments for 1–2 weeks
• Avoid intense exercise for 24 hours
• Follow your doctor’s instructions strictly

Summary

HArmonyCA is an innovative hybrid filler from Allergan that combines the benefits of Hyaluronic Acid and Calcium Hydroxyapatite. It delivers immediate volumizing effects while stimulating long-term collagen production. Ideal for facial contouring and lifting—particularly in the cheeks, jawline, and chin—HArmonyCA requires only a single treatment and offers results that last 1–2 years. It’s a great option for those seeking to address skin laxity and achieve a naturally youthful appearance.